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Which of the following factors does NOT contribute to fluid overload in AKI patients?

  1. Oliguria

  2. Anuria

  3. Increased urine output

  4. Dehydration

The correct answer is: Increased urine output

In acute kidney injury (AKI) patients, fluid overload is primarily associated with conditions where there is reduced urine output or an inability to excrete excess fluid. Oliguria, which is a significant decrease in urine production, and anuria, defined as the absence of urine output, both directly contribute to fluid retention and overload. In contrast, increased urine output indicates that the kidneys are functioning to some extent and are actively excreting fluid, which helps to prevent fluid overload. Thus, when urine output increases, it allows for the elimination of excess fluid from the body, contrary to the states that lead to fluid accumulation. Dehydration, on the other hand, typically leads to reduced fluid volume and does not contribute to fluid overload. Therefore, increased urine output is the factor that does not contribute to fluid overload in AKI patients, making it the correct choice in this context.