How does Amyloidosis contribute to Chronic Kidney Disease (CKD)?

Amyloidosis contributes to Chronic Kidney Disease (CKD) primarily through the accumulation of abnormal proteins, specifically amyloid fibrils, which deposit in various tissues and organs, including the kidneys. This abnormal protein accumulation leads to glomerular damage, as the presence of these fibrils disrupts normal kidney function and structure.

In the kidneys, amyloid deposits can infiltrate the glomeruli, which are the filtering units, disrupting their ability to filter blood effectively. This process causes glomerulosclerosis, or scarring of the kidney tissue, which can lead to proteinuria (the presence of excess proteins in the urine) and a gradual decline in renal function. Over time, this damage contributes to the progression of CKD, making it a significant factor in the pathophysiology of renal impairment associated with amyloidosis.

Understanding this mechanism is crucial for nephrology nurses, as identifying and managing the implications of amyloidosis in patients is essential to providing effective care for those at risk of or suffering from CKD.